A pivotal Phase III DBPC adaptive trial was conducted with PQ Grass 27600 SU. The primary endpoint EAACI-CSMS0–6 demonstrated a highly significant, ...

Infection and Immunity, Ahead of Print.

As metabolic dysfunction-associated steatotic liver disease (MASLD) frequently co-occurs in patients with chronic hepatitis B (CHB), the interplay between these two common liver conditions remains largely unexplored. We commend Osmani et al. for their insightful work investigating the liver immune activity in metabolic dysfunction-associated steatohepatitis (MASH), a progressive form of MASLD, comorbidity in patients with CHB.1 Their findings suggest that MASH comorbidity can reduce intrahepatic interferon pathway activity and macrophage gene signatures in HBeAg-negative CHB patients, potentially contributing to persistent infection and fibrosis.

It remains unclear whether phenotyping of type 2-high (T2-high) asthma can distinguish clinical characteristics and lung function trajectories in chil...

AbstractHerpes simplex virus (HSV) infection is one of the most prevalent viral infections worldwide. In general, host immunity is sufficient to clear viral shedding and recurrences, although it is insufficient to prevent subsequent virologic reactivations. In immunocompromised patients, prolonged and difficult-to-treat HSV infections may develop. The diagnosis of refractory HSV infection is based on the lack of clinical response to nucleoside analogs. Antiviral resistance is confirmed via genotypic and/or phenotypic testing. To provide consensus definitions of refractory and/or resistant (R/R) HSV mucocutaneous infections for clinical trial use, the HSV Resistance Working Group of the Transplant Associated Viral Infections Forum, which includes international clinicians, scientists, industry representatives, and regulatory officials, conducted a literature review of previously published data related to R/R HSV infections in immunocompromised patients. We propose definitions of R/R HSV mucocutaneous infections, which will be subject to re-evaluation and revision based on forthcoming data and future studies.