Chromoblastomycosis is a chronic fungal infection that affects the skin and subcutaneous tissue, primarily characterized by verrucous or nodular lesions. It often arises particularly in tropical and subtropical regions, where agricultural workers are most commonly affected. The most commonly isolated species are Fonsecaea pedrosoi and Cladophialophora carrionii. The disease progresses slowly, can be poorly responsive to antifungal therapy, and carries a high risk of recurrence. This report describes a challenging case of chromoblastomycosis of the right knee that proved unresponsive to several single-agent therapies but demonstrated improvement with combination antifungal treatment.

Researchers at the National Institutes of Health (NIH) have determined that dermatitis resulting from topical steroid withdrawal (TSW) is distinct from eczema and is caused by an excess of an essential chemical compound in the

Melanoma is the most dangerous type of skin cancer with poor therapy outcomes. Since malignant cells are more susceptible to Ca2+ overload than normal cells, activating Ca2+ overload-mediated apoptosis may be a promising strategy to inhibit melanoma progression. Hydrogen sulfide (H2S) donors can regulate Ca2+ channels, but their effects on melanoma cells remain unclear.