It has been 12 years since Science magazine published an original article on osteoarthritis (OA). The article by Yang et al. therefore marks a historic turning point.1 Beyond its editorial significance, this multidisciplinary work provides the first causal demonstration of an intestine–joint axis regulated by bile, the FXR receptor, and the incretin hormone GLP-1, paving the way for new therapeutic approaches. The urgency of the health issue justifies publication in such a prestigious journal.

It has been 12 years since Science magazine published an original article on osteoarthritis (OA). The article by Yang et al. therefore marks a historic turning point.1 Beyond its editorial significance, this multidisciplinary work provides the first causal demonstration of an intestine–joint axis regulated by bile, the FXR receptor, and the incretin hormone GLP-1, paving the way for new therapeutic approaches. The urgency of the health issue justifies publication in such a prestigious journal.

To evaluate the efficacy and safety of a combination of patented C. longa and B. serrata extracts (CBTIL) in patients with hand osteoarthritis compared with placebo.

Early study results demonstrate that rosnilimab may be safe and effective for patients with rheumatoid arthritis, reducing the signs and symptoms of RA by week 12 and achieving important primary and secondary study end points.

Bristol Myers Squibb (BMS) has presented new data from its phase 3 POETYK PsA-1 trial, showing that Sotyktu (deucravacitinib) significantly improved s...