Nature Reviews Gastroenterology & Hepatology, Published online: 22 May 2025; doi:10.1038/s41575-025-01068-6

Nature Reviews Gastroenterology & Hepatology, Published online: 22 May 2025; doi:10.1038/s41575-025-01071-x

Nature Reviews Gastroenterology & Hepatology, Published online: 22 May 2025; doi:10.1038/s41575-025-01068-6

AstraZeneca advances its ambition to eliminate cancer as a cause of death with new data across its diverse, industry─leading portfolio and pipeline at the American Society of Clinical Oncology (ASCO) Annual Meeting, 30th May to 3rd June, 2025.

Complications of endoscopic mucosal resection (EMR) of large colorectal polyps remain a concern.

The first patient has been dosed in the IDeate─Esophageal01 phase 3 trial evaluating the efficacy and safety of investigational ifinatamab deruxtecan (I─DXd) versus investigator's choice of chemotherapy in patients with

Steps Outlining the Engineering of Innervated Esophagus.

Stoop TF, Javed AA, Oba A, et al. Pancreatic cancer. Lancet 2025; 405: 1182–202—In this Seminar, several references cited in the text and non-text items have been corrected. These corrections have been made to the online version as of May 15, 2025.

Previous research has conducted meta-analyses on the diagnostic accuracy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB). However, studie...

Over the past 2 decades, there have been dramatic advances in the endoscopic management of patients with walled-off necrosis (WON), one of the feared sequelae of acute pancreatitis. This represents a patient group at high risk of adverse events such as sepsis and multiorgan failure, with reported mortality as high as 39%.1 The Dutch group had demonstrated the benefits of the step-up approach in treating patients with WON, initially using percutaneous drainage and subsequently resorting to minimally invasive surgical necrosectomy, an approach that confers superior patient outcomes in comparison with initial open surgical necrosectomy.