Cellulitis is a common acute skin and soft tissue infection with high rates of recurrence. Historically, guidelines for care have focused on pharmacol...

A retrospective cohort study comprised two distinct analyses comparing patients with AD under different treatments: (i) initiators of dupilumab (n?=?1...

The US Food and Drug Administration (FDA) has approved Dupixent (dupilumab) for the treatment of adult patients with bullous pemphigoid (BP).

The National Institute for Health and Care Excellence (NICE) has recommended Spevigo (spesolimab) for the treatment of generalised pustular psoriasis ...

Scratching in response to pruritus exacerbates dermatitis and is pathogenic in certain diseases; however, scratching is often a pleasurable sensation, suggesting that this action provides some benefit to the host. Upon activation through crosslinking of IgE to Fc?RI or through neuron-derived substance P binding of MRGPRB2 receptor, mast cells not only trigger histamine-induced vascular permeability, edema, and pruritus but also induce neutrophil recruitment. To more clearly understand the intersection between itch, scratching behavior, and inflammation, Liu et al (2025) found that the MRGPRA2-expressing itch-sensing neurons were required for scratching and inflammation.

Over the past 2 decades, innovations in trial design have significantly advanced the field of clinical research. Methodological developments, such as adaptive designs, basket trials, umbrella trials, and platform trials, along with technological advancements such as virtual studies have proven effective in tackling complex research questions and managing resource constraints. These approaches enable prospectively planned modifications to trial designs and facilitate addressing multiple research questions within a single infrastructure, with technological advancements such as virtual studies enhancing accessibility, efficiency, and patient engagement.

Keratinocyte carcinomas (KC), common skin cancers consisting predominantly of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC), affect more than 6 million patients per year (Hu et al. 2022). KC is associated with substantial morbidity, and treatment accounted for upwards of 0.14% of the Danish health care budget in 2013 (Bentzen et al. 2013). Broad-scope prevention modalities rely on avoidance of ultraviolet radiation (UVR) and application of sunscreen; however, compliance rates remain low even in at-risk populations (Goldenberg et al.