Bronchopulmonale dysplasie door vroeggeboorte bij volwassenen
Bronchopulmonale dysplasie (BPD) veroorzaakt nog steeds een hoge morbiditeit en mortaliteit in overlevenden van extreme prematuriteit. De ziekte wordt gekenmerkt door een vereenvoudiging van de alveolaire structuur; een kleiner aantal vergrote alveoli door een verminderde septatie en een dysmorfe groei van de pulmonale microvaten. Deze veranderingen leiden tot afwijkingen die voornamelijk van invloed zijn op de bronchiën, het longparenchym en de pulmonale vasculatuur.

Aanbevolen

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Pediatrie nieuws

[Correspondence] The INSPIRE study: RSV infection during infancy
thelancet.com
The effect of respiratory viral infections (eg, respiratory syncytial virus [RSV] infection, influenza, and COVID-19) in early life on the onset of childhood diseases (eg, asthma, mental health disorders, and childhood cancer) is of great concern globally. However, the challenges facing researchers, paediatricians, and policy makers are a short supply of evidence from well designed observational studies and inconsistent results in randomised controlled trials (RCTs). We were pleased to see that Christian Rosas-Salazar and colleagues1 used a combination of passive and active surveillance to better detect exposure to RSV infection in a population-based birth cohort study, which found that not being infected with RSV in the first year of life was associated with a 26% reduced risk of 5-year current asthma among healthy children born at term.
[Correspondence] The INSPIRE study: RSV infection during infancy
thelancet.com
The INSPIRE study by Christian Rosas-Salazar and colleagues1 examines the association between the absence of respiratory syncytial virus (RSV) infection in infancy and the reduced risk of childhood asthma. To ensure exposure during the first RSV season, the study specifically recruited children born between June and December in 2012 and 2013.2 However, the identification of RSV infection in infants was based on two methods: purposeful sampling of nasal wash (38%) for suspected acute respiratory tract infection, or a blood serology test conducted at age 1 year (62%).
[Correspondence] The INSPIRE study: RSV infection during infancy – Authors' reply
thelancet.com
Nin-Chieh Hsu and Chia-Hao Hsu postulate that our study design of including births between June and December led to overestimation of the calculated proportion of respiratory syncytial virus (RSV) infections during infancy.1 This assumption is incorrect for the following reasons: first, every child is exposed to the same number of RSV season months in the first 12 months of life regardless of birth month, so although the birth month would affect the age of infection, it is unlikely to affect the proportion of children infected with RSV during infancy.

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