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Oncologie bericht test


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COVID
Oligoprogressieve ziekte en langdurige respons bij eerstelijns osimertinib voor EGFR-gemuteerd NSCLC
EGFR-mutatie is de meest voorkomende behandelbare oncogene afwijking bij niet-kleincellig longcarcinoom (NSCLC), goed voor 10–15% van de Westerse patiënten. Osimertinib, een derde-generatie EGFR-tyrosinekinaseremmer (TKI), is de standaard eerstelijnsbehandeling voor gevorderd EGFR-gemuteerd NSCLC en toont hoge initiële effectiviteit. Uiteindelijk ontstaat echter vrijwel altijd resistentie, die zich kan uiten als oligoprogressieve ziekte (OPD), waarbij de tumor beperkt […]

Aanbevolen

Long
Nieuwe behandelstrategieën: ADC’s
prof.dr. E.F. Smit, longarts LUMC Er zijn meer dan 140 antibody drug conjugates (ADC’s) in klinische trials, maar er zijn problemen met toxiciteit e...
Neo-adjuvant behandelen: wie en hoe?
dr. Wouter de Jong, longarts UMCU Immunotherapie kan op verschillende manieren geïntegreerd worden in de behandelschema’s voor NSCLC.  Dr. Wou...

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Oncologie nieuws

Borst

Toon meer

Hoofd-hals

A Practical Method for Detecting Prognostic CD57+ T Cells in Head and Neck Cancer
onlinelibrary.wiley.com
Recurrence of head and neck squamous cell carcinoma (HNSCC) affects nearly half of patients and greatly reduces survival. There are currently no well-...
Patient?Reported Dysphagia and Swallowing?Related Quality of Life up to 10?Years After (Chemo)radiotherapy for Head and Neck Cancer: A Cross?Sectional Study
onlinelibrary.wiley.com
This study sought to better understand patient-reported dysphagia and swallowing-related quality of life (swQOL) in patients 6?months to 10?years foll...
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Long

Pattern of failure, impact of local therapy, and characteristics of long-term responders with advanced EGFR mutation positive non-small cell lung cancer treated with first-line osimertinib
lungcancerjournal.info
Epidermal growth factor receptor (EGFR) mutation is the most common actionable oncogenic alteration in non-small cell lung cancer (NSCLC), accounting for approximately 50?% of cases in Asian and 10–15?% of cases in Western populations [1]. The global phase III FLAURA trial established osimertinib as the standard first-line treatment for patients with advanced EGFR mutation positive NSCLC, demonstrating superior progression-free survival (PFS), overall survival (OS), and intracranial response rates, compared to first-generation EGFR tyrosine kinase inhibitors (TKIs) [2,3].
Pattern of failure, impact of local therapy, and characteristics of long-term responders with advanced EGFR mutation positive non-small cell lung cancer treated with first-line osimertinib
lungcancerjournal.info
Epidermal growth factor receptor (EGFR) mutation is the most common actionable oncogenic alteration in non-small cell lung cancer (NSCLC), accounting for approximately 50?% of cases in Asian and 10–15?% of cases in Western populations [1]. The global phase III FLAURA trial established osimertinib as the standard first-line treatment for patients with advanced EGFR mutation positive NSCLC, demonstrating superior progression-free survival (PFS), overall survival (OS), and intracranial response rates, compared to first-generation EGFR tyrosine kinase inhibitors (TKIs) [2,3].
Delivering equitable access to prehabilitation services to optimise outcomes for patients with lung cancer – Best practice recommendations from a UK roundtable event
lungcancerjournal.info
Prehabilitation is a component of the rehabilitation continuum, taking place either before a patient has received treatment and/or during treatment.[1] It aims to prepare patients for their treatment and facilitate a quicker return to health, with potential benefits including improved quality of life (QoL), reduced surgical complications, and decreased length of stay (LoS).[1–3].
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MDL

Two lenses, same picture: interpreting nal-IRI in biliary tract cancer
journal-of-hepatology.eu
We read with great interest the recent article by Yoo et al. reporting an individual patient-level pooled analysis of two multicenter randomized trials. [1]
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Pediatrie

Cancer in children living with HIV: challenges and perspectives in the antiretroviral therapy era
pubmed.ncbi.nlm.nih.gov
World J Pediatr. 2025 Sep 27. doi: 10.1007/s12519-025-00971-x. Online ahead of print.
Pediatric-Type Diffuse Low Grade Glioma
sciencedirect.com
Publication date: Available online 25 September 2025
UK MHRA grants marketing authorization to vorasidenib to treat patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation
pharmabiz.com
The UK Medicines and Healthcare products Regulatory Agency (MHRA) on 16th September 2025 has approved the medicine vorasidenib (Voranigo) to treat adults and children 12 years of age and older with certain types of brain
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Sarcoom

ENO1 promotes cancer metastasis via stimulating metabolism reprogramming in osteosarcoma
nature.com
British Journal of Cancer, Published online: 22 September 2025; doi:10.1038/s41416-025-03182-3
ENO1 promotes cancer metastasis via stimulating metabolism reprogramming in osteosarcoma
nature.com
British Journal of Cancer, Published online: 22 September 2025; doi:10.1038/s41416-025-03182-3