In 1997 a dog playfully jumped on me and shattered my hip. A tumor was discovered and it was osteosarcoma. I had a full left leg amputation with a six-month regimen of chemo as an in-hospital patient,...

Translocation (9;22), called Philadelphia chromosome (Ph) is the most common chromosomal abnormality in adult patients with acute lymphoblastic leukemia (ALL).1,2 Historically, Ph-positive ALL was associated with dismal prognosis and considered a very high-risk subtype.3 Results improved dramatically with the introduction of tyrosine kinase inhibitors (TKIs).3,4 The combination of imatinib with either corticosteroids or multi-agent chemotherapy results in 90-100% of complete remissions (CR).5-9 Unfortunately, without allogeneic hematopoietic cell transplantation (allo-HCT) most of the patients ultimately experience relapse.

Translocation (9;22), called Philadelphia chromosome (Ph) is the most common chromosomal abnormality in adult patients with acute lymphoblastic leukemia (ALL).1,2 Historically, Ph-positive ALL was associated with dismal prognosis and considered a very high-risk subtype.3 Results improved dramatically with the introduction of tyrosine kinase inhibitors (TKIs).3,4 The combination of imatinib with either corticosteroids or multi-agent chemotherapy results in 90-100% of complete remissions (CR).5-9 Unfortunately, without allogeneic hematopoietic cell transplantation (allo-HCT) most of the patients ultimately experience relapse.