Chromosomal abnormalities are the most common causes of spontaneous miscarriages in early pregnancy (?12?weeks of gestation), accounting for 60?% of all cases [1]. Aneuploidies can be caused either by fertilization of aneuploid gametes, due to segregation errors, or by non-disjunction events during embryonic development [2]. Most segregation errors occur in oocytes during meiosis I and are correlated with maternal age [3,4].

Chromosomal abnormalities are the most common causes of spontaneous miscarriages in early pregnancy (?12?weeks of gestation), accounting for 60?% of all cases [1]. Aneuploidies can be caused either by fertilization of aneuploid gametes, due to segregation errors, or by non-disjunction events during embryonic development [2]. Most segregation errors occur in oocytes during meiosis I and are correlated with maternal age [3,4].

Source: Journal of Pediatric and Adolescent Gynecology