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Hedendaagse chemotherapie voor acute lymfoblastische leukemie (ALL) bij kinderen wordt aangepast aan het risico op basis van klinische kenmerken, genetische componenten en minimale restziekte (MRD); de farmacologische basis van deze prognostische variabelen blijft echter onduidelijk. Zo gebruiken ALL-behandelingsregimes wereldwijd bijna uniform een identiek repertoire van conventionele chemotherapiegeneesmiddelen met weinig variatie in timing en intensiteit. Ze […]
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