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De behandeling van de novo patiënten met de ziekte van Parkinson begint met niet-medicamenteuze bewegingstherapie. De volgende stap in het behandelplan is het geven van medicijnen; eerste keus is Levodopa (L-DOPA) medicatie. Nadeel van dit type medicatie is dat het een verhoogd risico op dyskinesieën geeft. De medicijnen zijn na verloop van tijd ook minder […]
Espay AJ, Stocchi F, Pahwa R, et al. Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial. Lancet Neurol 2024; 23: 465–76—In this Article, the BouNDless Study Group has been updated. This correction has been made to the online version as of May 15, 2024.
Multiple system atrophy (MSA) is a sporadic adult-onset neurodegenerative disorder characterised by autonomic dysfunction, cerebellar ataxia and parkinsonism, each due to degeneration of the autonomic...
At the beginning of this decade, tremors rumbling within the inherited conventions of global health research erupted. Questions about the location, cultural backgrounds, and race and ethnicities of researchers, editors, and funders came under the spotlight. It seemed possible to imagine a world where new voices could be taken seriously and afforded the same attention and generosity routinely offered to white experts on public health in low-income and middle-income countries. Works of fiction can act as a reminder that these concerns are not unique to global health and bring fresh perspectives on representation, lived experiences, history, and hierarchies of knowledge.
Bradykinesia and rigidity are considered closely related motor signs in Parkinson disease (PD), but recent neurophysiological findings suggest distinct pathophysiological mechanisms. This study aims t...