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Voor de zorgverleners en patiënten Historisch gezien hebben zowel patiënten als clinici de voordelen van procedures zoals coronaire angiografie en PCI overschat en de risico's onderschat. Dit heeft geleid tot beperkingen in de adoptie van strategieën om bloedingen en contrast-geassocieerde acute kidney injury (acute nierbeschadiging; AKI) te vermijden bij patiënten met het hoogste risico. Het […]
Patiënten met urinewegstenen komen vaak op de spoedeisende hulp. Indien mogelijk wordt meestal als eerste gekozen voor observatie met een poging tot ...
Non-Hodgkin lymfoom Non-Hodgkin lymfoom (NHL) dat zich ontwikkelt na niertransplantatie behoort tot de post-transplantatie lymfoproliferatieve aandoen...
Higher thiazide doses are associated with greater reductions in urine calcium, which in turn correlate with fewer symptomatic kidney stone events, according to a new study.
A 32-year-old man with no previous medical history presented to the emergency department with right flank pain and gross hematuria. Laboratory test results on presentation showed severe acute kidney injury (AKI), with a serum creatinine level of 834.5 ?mol/l (vs. 65.4 ?mol/l in the past month), metabolic acidosis (bicarbonate levels: 17.8 mmol/L), hyperphosphatemia (3.13 mmol/L), and severe hyperuricemia (1785 umol/l). The complete laboratory test results are shown in Supplementary Table S1. An abdominal and pelvic computed tomography scan showed bilateral multiple kidney stones.
A 76-year-old woman with a history of hypertension, diabetes, atrial fibrillation, and nephrolithiasis was admitted for acute kidney injury. The serum creatinine level was 6.6 mg/dl, up from 0.8 mg/dl six weeks prior. Home medications included apixaban, hydrochlorothiazide, irbesartan, and metformin. Two weeks before admission, she received nitrofurantoin macrocrystals (macrodantin 100 mg by mouth twice a day for 5 days). Physical examination was positive for a blanching erythematous skin rash on the neck and leg swelling, without fever.
A new study has demonstrated a new, non-invasive imaging technique can accurately detect clear-cell renal cell carcinoma, the most common form of kidney cancer.
Mitochondrial cytopathies can have kidney involvement in up to half of cases. Their diagnosis is challenging due to phenotypic variability, lack of noninvasive tests to assess mitochondrial dysfunction and genetic heterogeneity. We report on a young adult male with hypertrophic cardiomyopathy (HCM) and chronic kidney disease (CKD) with sub-nephrotic proteinuria, who presented to the emergency department with kidney failure and hypervolemia requiring dialysis. A kidney biopsy showed focal segmental and global glomerulosclerosis, extensive foot process effacement, and abnormal mitochondria in podocytes and tubular epithelial cells; the genetic workup identified a rare FASTKD2 exon 2 variant, c.29G>C p.(Ser10Thr), in homozygosity; and functional mitochondrial assays in cultured skin fibroblasts showed reduction in FASTKD2 protein expression and moderate combined impairment in mitochondrial respiratory chain (MRC) assembly and function.
Mitochondrial cytopathies can have kidney involvement in up to half of cases. Their diagnosis is challenging due to phenotypic variability, lack of noninvasive tests to assess mitochondrial dysfunction and genetic heterogeneity. We report on a young adult male with hypertrophic cardiomyopathy (HCM) and chronic kidney disease (CKD) with sub-nephrotic proteinuria, who presented to the emergency department with kidney failure and hypervolemia requiring dialysis. A kidney biopsy showed focal segmental and global glomerulosclerosis, extensive foot process effacement, and abnormal mitochondria in podocytes and tubular epithelial cells; the genetic workup identified a rare FASTKD2 exon 2 variant, c.29G>C p.(Ser10Thr), in homozygosity; and functional mitochondrial assays in cultured skin fibroblasts showed reduction in FASTKD2 protein expression and moderate combined impairment in mitochondrial respiratory chain (MRC) assembly and function.
Topline results were announced from a phase 2b/3 study investigating clesrovimab as a preventive therapy for respiratory syncytial virus (RSV)-associa...
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