TANGO2 deficiency disorder (TDD) is a multisystem neurodegenerative disease first discovered by Lalani et al in 2016.1 This autosomal recessive disorder affects more than 8000 patients worldwide. About 1:500 individuals harbor a pathogenic TANGO2 variant that, notably, resides within the 22q11.21 locus. Thus, all patients with 22q11.21 deletion (DiGeorge) syndrome who are missing 1 copy of TANGO2 (transportation and golgi organization homolog 2) are at risk of having both disorders should they harbor a second pathogenic allele.

Before the 1980s, management of supraventricular arrhythmias that were refractory to drugs were treated surgically. The procedure involved thoracotomy, cardiotomy, and ligation or cryoablation of the atrioventricular (AV) junction. In the late 1970s, I conceived the idea of trying to replicate the surgical procedure but without the need for open heart surgery. A literature survey described a number of direct techniques used in animals to promote AV block, but I was struck by an abstract published by Beazell et al.

It is with great sadness but also with honor we write in memory of our dear friend and colleague David E. Haines, MD. David passed away suddenly on February 10, 2024. He was a dear friend and colleague of the Heart Rhythm Society and electrophysiologists around the world. David’s many scholarly contributions focused on ablation energy sources, starting in 1986 when he was at the University of Virginia (UVA) and radiofrequency ablation was being introduced. In this manner, David ushered in many ablation technologies and quickly became an icon for ablation trials, both preclinical and clinical, and taught us about best practices.