The autonomic nervous system (ANS) is critical to atrial fibrillation (AF) pathophysiology, but it is often difficult to differentiate vagal and adrenergic AF due to complex physiological interactions.1 Early repolarization patterns (ERPs) on electrocardiograms are associated with idiopathic ventricular fibrillation, which often develops in association with increased vagal tone.2 We previously reported that ERPs were associated with increased susceptibility to AF.3 In this study, we evaluated the association between ERP and vagally-mediated AF by assessing the autonomic function using heart rate variability (HRV) and the efficacy of catheter ablation (CA).

The autonomic nervous system (ANS) is critical to atrial fibrillation (AF) pathophysiology, but it is often difficult to differentiate vagal and adrenergic AF due to complex physiological interactions.1 Early repolarization patterns (ERPs) on electrocardiograms are associated with idiopathic ventricular fibrillation, which often develops in association with increased vagal tone.2 We previously reported that ERPs were associated with increased susceptibility to AF.3 In this study, we evaluated the association between ERP and vagally-mediated AF by assessing the autonomic function using heart rate variability (HRV) and the efficacy of catheter ablation (CA).

In this register-based study of 1064 atrial fibrillation patients, late cryoballoon ablation (?3 years after first AF-diagnosis) was associated with a significantly higher atrial fibrillation recurren...