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De Epidermal Growth Factor Receptor (EGFR)-mutatie is de meest voorkomende behandelbare oncogene afwijking bij niet-kleincellig longcarcinoom (NSCLC), goed voor circa 10–15% van de Westerse NSCLC-patiënten. Osimertinib, een derde-generatie EGFR-tyrosinekinaseremmer (TKI), is de standaard eerstelijnsbehandeling voor gevorderd EGFR-gemuteerd NSCLC en toont hoge initiële effectiviteit. Echter ontstaat vrijwel altijd resistentie tegen osimertinib, die zich kan uiten als […]
prof.dr. E.F. Smit, longarts LUMC Er zijn meer dan 140 antibody drug conjugates (ADC’s) in klinische trials, maar er zijn problemen met toxiciteit e...
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